Are more men with breast cancer opting for prophylactic mastectomy?

STUDY AT A GLANCE

This study is about:

Trends and factors associated with the decision to undergo prophylactic double mastectomy among men with cancer in one breast.

Why is this study important?

Researchers have seen the rates of double mastectomy increase in women with breast cancer but they do not know if this increase is also true for men.

Key study findings:

The rate of prophylactic mastectomy doubled (from 3% to 6%), but the overall number is still very small, with only 106 of 1884 men with invasive cancer in one breast choosing to undergo double mastectomy.

The factors associated with a higher likelihood of double mastectomy include: younger age, white race, and having private insurance rather than Medicaid.

What does this mean for me?

This study indicates an increase in the rate of men choosing double mastectomy between 2004-2005 and 2010-2011. However, it is important to note that most men with breast cancer have a unilateral mastectomy (approximately 75% of men in 2004-2005 and 2010-2011 chose this option). The decision to undergo a single or double mastectomy should be a personal, individual one, made in consultation with your healthcare provider.

Questions to ask your health care provider:

What are the pros and cons of each type of surgery?

What are the costs and complications that can be associated with double mastectomy?

Is A lumpectomy is a surgery that is performed to remove a lump in the breast often to diagnose or treat breast cancer.  ”>lumpectomy an option?

As a man with breast cancer, should I consider genetic counseling and/or BRCA refers to two genes BRCA1 and BRCA2. Mutations in these genes cause an increased risk for breast, ovarian, prostate, pancreatic, and melanoma cancers. Although BRCA1 and BRCA2 are often referenced together, they are separate genes. Mutations in BRCA1 and BRCA2 cause slightly different risks for different cancers.  Also see BRCA1, BRCA2 and HBOC. ”>BRCA testing?

A male blood relative has had breast cancer, should I be concerned that it is hereditary?

IN DEPTH REVIEW OF RESEARCH

Study background:

Researchers have noted increased rates of double mastectomy in women diagnosed with invasive cancer in one breast. This trend is especially true for younger women. Factors that researchers believe contribute to the increased rates of double mastectomy include:

increased BRCA refers to two genes BRCA1 and BRCA2. Mutations in these genes cause an increased risk for breast, ovarian, prostate, pancreatic, and melanoma cancers. Although BRCA1 and BRCA2 are often referenced together, they are separate genes. Mutations in BRCA1 and BRCA2 cause slightly different risks for different cancers.  Also see BRCA1, BRCA2 and HBOC. ”>BRCA testing

use of Magnetic Resonance Imaging; a technique for looking for abnormalities such as cancer using magnetic fields. Breast MRI is typically recommended as a screening tool for breast cancer in high-risk women and is often used to follow up on a breast abnormality seen on mammogram. ”>MRI (some research suggests Magnetic Resonance Imaging; a technique for looking for abnormalities such as cancer using magnetic fields. Breast MRI is typically recommended as a screening tool for breast cancer in high-risk women and is often used to follow up on a breast abnormality seen on mammogram. ”>MRI findings cause patients to worry about cancer developing in the opposite breast)

the desire to achieve symmetry through reconstructive surgery

Although more women are opting to undergo double mastectomy – which comes with a risk of complications and costs – studies have not shown a survival benefit from the surgery. Unlike women, the double mastectomy rates among men with cancer in one breast and the various factors that contribute to their decisions are unknown.

Researchers of this study wanted to know:

Whether the double mastectomy rate in men has increased.

Population(s) looked at in the study:

6332 men who:

Were at least 20 years old

Had been diagnosed with Stage is a term used to describe how much a cancer has spread. Cancers are staged from stage 0 (preinvasive cancer) to stage 4. Although staging varies by cancer type, usually the lower the number, the less the cancer has spread. ”>stage I-III invasive breast cancer in one breast

Underwent surgery between 2004 and 2011

Study finding(s):

Comparing the double mastectomy rates during 2004-2005 to 2010-2011 indicates that the rate of this surgery increased from 3% to approximately 6%.
- 35 of 1166 men with invasive cancer in one breast chose to undergo double mastectomy in 2004-2005 while 106 of 1884 men with invasive cancer in one breast chose to undergo double mastectomy in 2010-2011

The factors that were associated with a higher likelihood of double mastectomy were:
- younger age
- white race
- having private insurance rather than Medicaid.

Limitations:

The researchers note that studies have found that increased BRCA refers to two genes BRCA1 and BRCA2. Mutations in these genes cause an increased risk for breast, ovarian, prostate, pancreatic, and melanoma cancers. Although BRCA1 and BRCA2 are often referenced together, they are separate genes. Mutations in BRCA1 and BRCA2 cause slightly different risks for different cancers.  Also see BRCA1, BRCA2 and HBOC. ”>BRCA testing has increased prophylactic mastectomy rates in women with breast cancer. This research was not able to look at the BRCA refers to two genes BRCA1 and BRCA2. Mutations in these genes cause an increased risk for breast, ovarian, prostate, pancreatic, and melanoma cancers. Although BRCA1 and BRCA2 are often referenced together, they are separate genes. Mutations in BRCA1 and BRCA2 cause slightly different risks for different cancers.  Also see BRCA1, BRCA2 and HBOC. ”>BRCA status of those in the study population. However, because 40% of male breast cancer is linked to BRCA2 is a gene found on chromosome 13. Mutations in BRCA2 increase the risk for cancers including breast, ovarian, pancreatic, prostate, melanoma and possibly other cancers. BRCA2 mutations are among the genes associated with Hereditary Breast and Ovarian Cancer Syndrome, also known as HBOC.  ”>BRCA2 mutations, it is possible that a sizable number of study participants may have been found to be BRCA refers to two genes BRCA1 and BRCA2. Mutations in these genes cause an increased risk for breast, ovarian, prostate, pancreatic, and melanoma cancers. Although BRCA1 and BRCA2 are often referenced together, they are separate genes. Mutations in BRCA1 and BRCA2 cause slightly different risks for different cancers.  Also see BRCA1, BRCA2 and HBOC. ”>BRCA carriers.

Discussion:

According to study author Dr. Ahmedin Jemal, quoted in a Newsweek, article, “it’s important for male patients to ask a physician about their individual risk for Breast cancer in the other breast of patients who are already diagnosed with breast cancer.  ”>contralateral breast cancer before making any decisions about the surgery…It’s only the patients at high risk who are likely to benefit from the procedure.”

Although not as much research has been done on men with breast cancer, we do know that those with a BRCA2 is a gene found on chromosome 13. Mutations in BRCA2 increase the risk for cancers including breast, ovarian, pancreatic, prostate, melanoma and possibly other cancers. BRCA2 mutations are among the genes associated with Hereditary Breast and Ovarian Cancer Syndrome, also known as HBOC.  ”>BRCA2 mutation have a 7% risk of developing breast cancer by age 70. No studies, however, look at the risk of a second breast cancer diagnosis in men with BRCA2 is a gene found on chromosome 13. Mutations in BRCA2 increase the risk for cancers including breast, ovarian, pancreatic, prostate, melanoma and possibly other cancers. BRCA2 mutations are among the genes associated with Hereditary Breast and Ovarian Cancer Syndrome, also known as HBOC.  ”>BRCA2 mutations. By looking only at male survival rates and failing to also look at recurrence rates, researchers are unable to consider the possibility that double mastectomy may be decreasing the occurrence of a second cancer, helping these patients avoid further treatment.

In women without a BRCA refers to two genes BRCA1 and BRCA2. Mutations in these genes cause an increased risk for breast, ovarian, prostate, pancreatic, and melanoma cancers. Although BRCA1 and BRCA2 are often referenced together, they are separate genes. Mutations in BRCA1 and BRCA2 cause slightly different risks for different cancers.  Also see BRCA1, BRCA2 and HBOC. ”>BRCA mutation, the chance of a second breast cancer diagnosis 10 years after the initial diagnosis is approximately 10%. The risk is 10%-30% for breast cancer survivors with a BRCA refers to two genes BRCA1 and BRCA2. Mutations in these genes cause an increased risk for breast, ovarian, prostate, pancreatic, and melanoma cancers. Although BRCA1 and BRCA2 are often referenced together, they are separate genes. Mutations in BRCA1 and BRCA2 cause slightly different risks for different cancers.  Also see BRCA1, BRCA2 and HBOC. ”>BRCA mutation.

Additionally, it is important to note that the researchers were able to see a significant difference in the rate of double mastectomy only between the years 2004-2005 and 2010-2011. They were unable to see any significant differences when comparing rates in 2004-2005 to those in 2006-2007 or in 2008-2009. Although the lack of a rate increase between 2006 and 2009 may strengthen the researchers’ argument that the increased rate of double mastectomy is, in fact, new, more data needs to be collected to ensure the trend is stable rather than something unique to 2010 and 2011.

Conclusions:

For both men and women, the decision to undergo a prophylactic mastectomy should be an individual, personal one, made by patients in consultation with their healthcare providers. Although the data from this study indicate the rates of this surgery in men with breast cancer have increased, more research is needed, both to understand why the rates have increased and to determine if there is a subset of men who will benefit from the procedure.

References:

Firger, J. “Rise Seen in Preventative Mastectomy for Male Breast Cancer Patients.” Newsweek. Published September 2, 2015.

Jemal A, Lin C, DeSantis C et al. “Temporal Trends in and Factors Associated with Contralateral Prophylatic Mastectomy Among US Men With Breast Cancer.” JAMA Surgery, Initially published online September 2, 2015.

Komen. “Inherited Gene Mutations,” updated 1/22/15

Schrag D, Kuntz KM, Garber JE, et al. “Life expectancy gains from cancer prevention strategies for women with breast cancer and BRCA1 is a gene found on chromosome 17. Mutations in BRCA1 increase the risk for cancers including breast, ovarian, pancreatic, prostate, melanoma and possibly other cancers. BRCA1 mutations are among the genes associated with Hereditary Breast and Ovarian Cancer Syndrome, also known as HBOC.  ”>BRCA1 or BRCA2 mutations.” JAMA. 283 (5): 617-24, February 2, 2000.

Tai YC, Domchek S, Parmigiani G, et al. “Breast cancer risk among male BRCA1 is a gene found on chromosome 17. Mutations in BRCA1 increase the risk for cancers including breast, ovarian, pancreatic, prostate, melanoma and possibly other cancers. BRCA1 mutations are among the genes associated with Hereditary Breast and Ovarian Cancer Syndrome, also known as HBOC.  ”>BRCA1 and BRCA2 is a gene found on chromosome 13. Mutations in BRCA2 increase the risk for cancers including breast, ovarian, pancreatic, prostate, melanoma and possibly other cancers. BRCA2 mutations are among the genes associated with Hereditary Breast and Ovarian Cancer Syndrome, also known as HBOC.  ”>BRCA2 mutation carriers.” J Natl Cancer Inst. 99(23): 1811-4, December 5, 2007.

Article Source